Dr. Carl H. June uses an experimental HIV-based therapy on leukemia patients (Still from vimeo.com/Rich Tolsma Productions)
A Utah man’s leukemia is in remission, thanks to an experimental therapy. Doctors injected him with HIV-infused white blood cells, which were programmed to recognize, target and kill the cancer.
Marshall Jensen was diagnosed with acute lymphoblastic leukemia in early 2012. He then began searching for a treatment that would force the aggressive and often deadly blood cancer into remission. After traveling the country for unsuccessful surgeries, treatments and procedures, he learned about researchers at Penn Medicine in Philadelphia, Pennsylvania, where they’ve spent two decades developing a breakthrough experimental treatment that kills cancer in otherwise incurable leukemia patients, KSL reported.
Image from facebook.com (Marshall Jensen)
“It felt right; and we didn’t know how we were going to get out there, what we were going to do, but it worked,” Jensen said. “By God’s grace I was able to come back.”
The researchers at Penn Medicine, led by Dr. Carl June, focus on using patient’s own immune cells ‒ known as T-cells, a type of white blood cells ‒ and HIV, the virus that causes AIDS.
“It’s a disabled virus,” June explained to KSL. “But it retains the one essential feature of HIV, which is the ability to insert new genes into cells.”
The experimental therapy, called T-cell immunotherapy, works by removing billions of the patient’s T-cells from the blood and genetically modifying or reprogramming them with a disabled form of HIV in the laboratory. This modification or reprogramming allows them to potentially target and kill their own malignant cells. The modified cells ‒ now called CTL019 cells ‒ are then grown in the laboratory and re-infused into the patient. When the patient’s own T-cells recognize and bind to the malignant cell, they have the ability to become activated and kill it, according to the Abramson Cancer Center.
June told KSL that the CTL019 cells, which he refers to as “serial killers,” stay dormant in the body unless the cancer returns.
The link between leukemia and HIV goes back to 2006, when Timothy Brown, an HIV-positive patient was diagnosed with acute myeloid leukemia. During the course of his treatment, he eventually had a bone marrow transplant from a donor with a rare genetic mutation. The transplant not only treated Brown’s leukemia but had also eliminated the HIV from his system, the doctors treating him announced in a study published in the New England Journal of Medicine. Brown, who became known as the Berlin Patient, became the first man to ever be fully cured of HIV.
Read more at RT News